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Metabolism of (R)-Praziquantel versus the Activation of a Parasite Transient Receptor Potential Melastatin Ion Channel.
Friedrich, Lukas; Park, Sang-Kyu; Ballard, Peter; Ho Baeurle, Tobias Hyun; Maillard, David; Bödding, Matthias; Keiser, Jennifer; Marchant, Jonathan S; Spangenberg, Thomas.
Afiliação
  • Friedrich L; Global Research & Development, Merck Healthcare KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Park SK; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee WI, 53226, USA.
  • Ballard P; PB DMPK Consulting Ltd., Chinley, SK236BQ, UK.
  • Ho Baeurle TH; Site Management-Analytics, Merck Healthcare KGaA, 64293, Darmstadt, Germany.
  • Maillard D; Central Process Development-Downstream Processing Services, Merck Electronics KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Bödding M; Merck Healthcare KGaA, Frankfurter Str. 250, 64293, Darmstadt, Germany.
  • Keiser J; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Kreuzstr. 2, 4123, Allschwil, Switzerland.
  • Marchant JS; Helminth Drug Development Unit, University of Basel, Basel, Switzerland.
  • Spangenberg T; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee WI, 53226, USA.
ChemMedChem ; 18(18): e202300140, 2023 09 15.
Article em En | MEDLINE | ID: mdl-37272317
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parasitos / Canais de Potencial de Receptor Transitório / Canais de Cátion TRPM / Anti-Helmínticos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parasitos / Canais de Potencial de Receptor Transitório / Canais de Cátion TRPM / Anti-Helmínticos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article