Cemtirestat, an aldose reductase inhibitor and antioxidant compound, induces ocular defense against oxidative and inflammatory stress in rat models for glycotoxicity.

Reihanifar, Tala; Sahin, Muzaffer; Stefek, Milan; Ceylan, Asli F; Karasu, Çimen

Reihanifar, Tala; Sahin, Muzaffer; Stefek, Milan; Ceylan, Asli F; Karasu, Çimen.

Afiliação

Reihanifar T; Cellular Stress Response and Signal Transduction Research Laboratory, Department of Medical Pharmacology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Sahin M; Department of Ophthalmology, Ankara City Hospital General Hospital (MHC), Eye Section, Ankara, Turkey.
Stefek M; Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Ceylan AF; Department of Medical Pharmacology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey.
Karasu Ç; Cellular Stress Response and Signal Transduction Research Laboratory, Department of Medical Pharmacology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Cell Biochem Funct ; 41(6): 622-632, 2023 Aug.

Article em En | MEDLINE | ID: mdl-37272424

Assuntos

Aldeído Redutase; Antioxidantes; Animais; Ratos; Antioxidantes/farmacologia; Fator A de Crescimento do Endotélio Vascular; Inibidores Enzimáticos; Estresse Oxidativo; Produtos Finais de Glicação Avançada

Palavras-chave

aldose reductase; cemtirestat; diabetes mellitus; epelrastat; eye; oxidative stress; retinopathy; stobadine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aldeído Redutase / Antioxidantes Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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