Chromium-Catalyzed Diastereoselective Synthesis of Conformationally Constrained Spirotetrahydroquinolines.
Org Lett
; 25(23): 4241-4246, 2023 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-37272613
ABSTRACT
We report the diastereoselective cyclization of anilines with cyclobutanones and congeners by chromium catalysis. This reaction can link two strained four-membered rings with tetrahydroquinolines by forming four bonds in a diastereocontrolled manner, forming medicinally interesting cyclobutane-fused and constrained spirotetrahydroquinolines (STHQs) and complex multiple spiro carbon-containing polyazacycles. The constrained STHQs have been used as versatile feedstocks to derive a range of oxygen-, nitrogen-, and thio-substituted spiro analogues, and dioxygen-incorporated spiroazacycles.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromo
/
Ciclobutanos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article