Upregulation of lysine-specific demethylase 6B aggravates inflammatory pain through H3K27me3 demethylation-dependent production of TNF-&#945; in the dorsal root ganglia and spinal dorsal horn in rats.

Qiao, Yiming; Li, Liren; Bai, Liying; Gao, Yan; Yang, Yin; Wang, Li; Wang, Xueli; Liang, Zongyi; Xu, Ji-Tian

Upregulation of lysine-specific demethylase 6B aggravates inflammatory pain through H3K27me3 demethylation-dependent production of TNF-α in the dorsal root ganglia and spinal dorsal horn in rats.

Qiao, Yiming; Li, Liren; Bai, Liying; Gao, Yan; Yang, Yin; Wang, Li; Wang, Xueli; Liang, Zongyi; Xu, Ji-Tian.

Afiliação

Qiao Y; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Li L; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Bai L; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Gao Y; Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Yang Y; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Wang L; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Wang X; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Liang Z; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Xu JT; Department of Physiology and Neurobiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.

CNS Neurosci Ther ; 29(11): 3479-3492, 2023 11.

Article em En | MEDLINE | ID: mdl-37287407

Assuntos

Gânglios Espinais; Histonas; Corno Dorsal da Medula Espinal; Fator de Necrose Tumoral alfa; Animais; Ratos; Desmetilação; Adjuvante de Freund/toxicidade; Gânglios Espinais/metabolismo; Histonas/metabolismo; Hiperalgesia/metabolismo; Lisina/metabolismo; Dor/metabolismo; Medição da Dor; Ratos Sprague-Dawley; RNA Interferente Pequeno/metabolismo; Corno Dorsal da Medula Espinal/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Regulação para Cima

Palavras-chave

TNF-α; dorsal root ganglia; epigenetics; inflammatory pain; lysine-specific demethylase 6B; spinal cord

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Histonas / Fator de Necrose Tumoral alfa / Corno Dorsal da Medula Espinal / Gânglios Espinais Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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