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Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase.
Singh, Isha; Li, Fengling; Fink, Elissa A; Chau, Irene; Li, Alice; Rodriguez-Hernández, Annía; Glenn, Isabella; Zapatero-Belinchón, Francisco J; Rodriguez, M Luis; Devkota, Kanchan; Deng, Zhijie; White, Kris; Wan, Xiaobo; Tolmachova, Nataliya A; Moroz, Yurii S; Kaniskan, H Ümit; Ott, Melanie; García-Sastre, Adolfo; Jin, Jian; Fujimori, Danica Galonic; Irwin, John J; Vedadi, Masoud; Shoichet, Brian K.
Afiliação
  • Singh I; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94143, United States.
  • Li F; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Fink EA; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94143, United States.
  • Chau I; Graduate Program in Biophysics, University of California San Francisco, San Francisco, California 94143, United States.
  • Li A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Rodriguez-Hernández A; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
  • Glenn I; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
  • Zapatero-Belinchón FJ; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States.
  • Rodriguez ML; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94143, United States.
  • Devkota K; Gladstone Institutes, San Francisco, California 94158, United States.
  • Deng Z; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
  • White K; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
  • Wan X; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  • Tolmachova NA; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
  • Moroz YS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
  • Kaniskan HÜ; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
  • Ott M; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94143, United States.
  • García-Sastre A; Enamine Ltd, Kyïv 02094, Ukraine.
  • Jin J; Institute of Bioorganic Chemistry and Petrochemistry, National Ukrainian Academy of Science, Kyïv 02660, Ukraine.
  • Fujimori DG; National Taras Shevchenko University of Kyïv, Kyïv 01601, Ukraine.
  • Irwin JJ; Chemspace, Riga LV-1082, Latvia.
  • Vedadi M; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.
  • Shoichet BK; Gladstone Institutes, San Francisco, California 94158, United States.
J Med Chem ; 66(12): 7785-7803, 2023 06 22.
Article em En | MEDLINE | ID: mdl-37294077
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Metiltransferases Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: COVID-19 / Metiltransferases Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article