Cytostatic activity of daunorubicin analogs containing daunosamine as furanoside.
Arzneimittelforschung
; 36(5): 786-9, 1986 May.
Article
em En
| MEDLINE
| ID: mdl-3730013
ABSTRACT
This paper describes the synthesis of daunorubicin (daunomycin) analogs, differing from the natural antibiotics in the ring size of the sugar moiety (furanosides instead of pyranosides). Both, the 5-O-methyl derivative 7 as well as the daunosaminofuranoside 16 were less active cytostatics than doxorubicin (adriamycin), but 16 was also much less toxic, consequently its therapeutic index is more favourable.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Daunorrubicina
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article