Deconstructing interindividual variability in energy metabolism: implications for metabolic health.

A person's metabolic rate corresponds to the whole body level sum of all oxidative reactions occurring on the cellular level. The energy expenditure (EE) can be categorized into various obligatory and facultative processes. In sedentary adults, basal metabolic rate is the largest contributor to total daily EE, and interindividual variability can be significant. Additional EE is required for digesting and metabolizing food, thermoregulatory adaptation to cold, and to support exercise and nonexercise body movements. Interindividual variability also exists for these EE processes, even after controlling for known factors. The complex mechanisms of interindividual variability in EE can have genetic and environmental origins and require further investigation. Exploration of interindividual variability in EE and its underlying factors holds importance to metabolic health, as it may predict disease risk, and be useful in the personalization of preventative and treatment strategies.