Pertussis toxin inhibits the antinociceptive action of morphine in the rat.
Eur J Pharmacol
; 124(3): 357-9, 1986 May 27.
Article
em En
| MEDLINE
| ID: mdl-3732384
ABSTRACT
The influence of pertussis toxin (PTX) injected intracerebroventricularly (i.c.v., 0.5 micrograms) on the analgesic effect induced in the rat by i.c.v. injection of morphine (5 micrograms) was studied. Morphine analgesia was unaffected 24 h after toxin administration, but there was a significant decrease after 6 days. Therefore a PTX-sensitive substrate, probably a guanine nucleotide regulatory protein could be involved in the coupling of opiate receptors to cellular effectors responsible for the expression of the antinociceptive action of morphine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Virulência de Bordetella
/
Toxina Pertussis
/
Analgésicos
/
Morfina
Limite:
Animals
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article