Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With <i>KRAS<sup>G12C</sup></i>-Mutated Non-Small-Cell Lung Cancer Who Have Untreated CNS Metastases.

Negrao, Marcelo V; Spira, Alexander I; Heist, Rebecca S; Jänne, Pasi A; Pacheco, Jose M; Weiss, Jared; Gadgeel, Shirish M; Velastegui, Karen; Yang, Wenjing; Der-Torossian, Hirak; Christensen, James G; Sabari, Joshua K

Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With KRAS^G12C-Mutated Non-Small-Cell Lung Cancer Who Have Untreated CNS Metastases.

Negrao, Marcelo V; Spira, Alexander I; Heist, Rebecca S; Jänne, Pasi A; Pacheco, Jose M; Weiss, Jared; Gadgeel, Shirish M; Velastegui, Karen; Yang, Wenjing; Der-Torossian, Hirak; Christensen, James G; Sabari, Joshua K.

Afiliação

Negrao MV; Department of Thoracic/Head & Neck Medical Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX.
Spira AI; Virginia Cancer Specialists, Fairfax, VA.
Heist RS; US Oncology Research, The Woodlands, TX.
Jänne PA; NEXT Oncology, Fairfax, VA.
Pacheco JM; Massachusetts General Hospital, Boston, MA.
Weiss J; Dana-Farber Cancer Institute, Boston, MA.
Gadgeel SM; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Velastegui K; Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC.
Yang W; Henry Ford Cancer Institute, Detroit, MI.
Der-Torossian H; Mirati Therapeutics, Inc, San Diego, CA.
Christensen JG; Mirati Therapeutics, Inc, San Diego, CA.
Sabari JK; Mirati Therapeutics, Inc, San Diego, CA.

J Clin Oncol ; 41(28): 4472-4477, 2023 10 01.

Article em En | MEDLINE | ID: mdl-37327468

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias do Sistema Nervoso Central; Neoplasias Pulmonares; Segunda Neoplasia Primária; Humanos; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Proteínas Proto-Oncogênicas p21(ras)/genética; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Acetonitrilas; Neoplasias do Sistema Nervoso Central/tratamento farmacológico; Neoplasias do Sistema Nervoso Central/genética; Mutação

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Segunda Neoplasia Primária / Neoplasias do Sistema Nervoso Central / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Tipo de estudo: Clinical_trials Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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