Asp179 in the class A ß-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis.

van Alen, Ilona; Chikunova, Aleksandra; van Zanten, Danny B; de Block, Amber A; Timmer, Monika; Brünle, Steffen; Ubbink, Marcellus

van Alen, Ilona; Chikunova, Aleksandra; van Zanten, Danny B; de Block, Amber A; Timmer, Monika; Brünle, Steffen; Ubbink, Marcellus.

Afiliação

van Alen I; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Chikunova A; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
van Zanten DB; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
de Block AA; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Timmer M; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Brünle S; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Ubbink M; Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

FEBS J ; 290(20): 4933-4949, 2023 10.

Article em En | MEDLINE | ID: mdl-37335937

Assuntos

Mycobacterium tuberculosis; Mycobacterium tuberculosis/metabolismo; beta-Lactamases/química; Epistasia Genética; Ceftazidima/metabolismo; Penicilinas; Antibacterianos/metabolismo

Palavras-chave

crystal structure; enzyme; protein evolution; ß-lactamase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mycobacterium tuberculosis Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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