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Pre-admission ambient air pollution and blood soot particles predict hospitalisation outcomes in COVID-19 patients.
Vos, Stijn; De Waele, Elien; Goeminne, Pieter; Bijnens, Esmée M; Bongaerts, Eva; Martens, Dries S; Malina, Robert; Ameloot, Marcel; Dams, Karolien; De Weerdt, Annick; Dewyspelaere, Geert; Jacobs, Rita; Mistiaen, Geert; Jorens, Philippe; Nawrot, Tim S.
Afiliação
  • Vos S; Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
  • De Waele E; S. Vos and E. De Waele contributed equally.
  • Goeminne P; Hospital VITAZ Sint-Niklaas, Sint-Niklaas, Belgium.
  • Bijnens EM; S. Vos and E. De Waele contributed equally.
  • Bongaerts E; Hospital VITAZ Sint-Niklaas, Sint-Niklaas, Belgium.
  • Martens DS; Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
  • Malina R; Department of Environmental Sciences, Faculty of Science, Open University, Heerlen, The Netherlands.
  • Ameloot M; Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
  • Dams K; Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
  • De Weerdt A; Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
  • Dewyspelaere G; Biomedical Research Institute, Hasselt University, Hasselt, Belgium.
  • Jacobs R; Antwerp University Hospital, University of Antwerp (LEMP), Edegem, Belgium.
  • Mistiaen G; Antwerp University Hospital, University of Antwerp (LEMP), Edegem, Belgium.
  • Jorens P; Hospital VITAZ Sint-Niklaas, Sint-Niklaas, Belgium.
  • Nawrot TS; Antwerp University Hospital, University of Antwerp (LEMP), Edegem, Belgium.
Eur Respir J ; 62(1)2023 07.
Article em En | MEDLINE | ID: mdl-37343978
BACKGROUND: Air pollution exposure is one of the major risk factors for aggravation of respiratory diseases. We investigated whether exposure to air pollution and accumulated black carbon (BC) particles in blood were associated with coronavirus disease 2019 (COVID-19) disease severity, including the risk for intensive care unit (ICU) admission and duration of hospitalisation. METHODS: From May 2020 until March 2021, 328 hospitalised COVID-19 patients (29% at intensive care) were recruited from two hospitals in Belgium. Daily exposure levels (from 2016 to 2019) for particulate matter with aerodynamic diameter <2.5 µm and <10 µm (PM2.5 and PM10, respectively), nitrogen dioxide (NO2) and BC were modelled using a high-resolution spatiotemporal model. Blood BC particles (internal exposure to nano-sized particles) were quantified using pulsed laser illumination. Primary clinical parameters and outcomes included duration of hospitalisation and risk of ICU admission. RESULTS: Independent of potential confounders, an interquartile range (IQR) increase in exposure in the week before admission was associated with increased duration of hospitalisation (PM2.5 +4.13 (95% CI 0.74-7.53) days, PM10 +4.04 (95% CI 1.24-6.83) days and NO2 +4.54 (95% CI 1.53-7.54) days); similar effects were observed for long-term NO2 and BC exposure on hospitalisation duration. These effect sizes for an IQR increase in air pollution on hospitalisation duration were equivalent to the effect of a 10-year increase in age on hospitalisation duration. Furthermore, for an IQR higher blood BC load, the OR for ICU admission was 1.33 (95% CI 1.07-1.65). CONCLUSIONS: In hospitalised COVID-19 patients, higher pre-admission ambient air pollution and blood BC levels predicted adverse outcomes. Our findings imply that air pollution exposure influences COVID-19 severity and therefore the burden on medical care systems during the COVID-19 pandemic.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Atmosféricos / Poluição do Ar / COVID-19 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poluentes Atmosféricos / Poluição do Ar / COVID-19 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article