Adverse effects of an aldosterone synthase (CYP11B2) inhibitor, fadrozole (FAD286), on inflamed rat colon.

Launonen, Hanna; Luiskari, Lotta; Linden, Jere; Siltari, Aino; Salmenkari, Hanne; Korpela, Riitta; Vapaatalo, Heikki

Launonen, Hanna; Luiskari, Lotta; Linden, Jere; Siltari, Aino; Salmenkari, Hanne; Korpela, Riitta; Vapaatalo, Heikki.

Afiliação

Launonen H; Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland.
Luiskari L; Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland.
Linden J; Faculty of Veterinary Medicine, Department of Veterinary Biosciences and Finnish Centre for Laboratory Animal Pathology (FCLAP), HiLIFE, University of Helsinki, Helsinki, Finland.
Siltari A; Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland.
Salmenkari H; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Korpela R; Folkhälsan Research Center, Folkhälsan Institute of Genetics, Helsinki, Finland.
Vapaatalo H; Abdominal Center, Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Basic Clin Pharmacol Toxicol ; 133(3): 211-225, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37345281

Assuntos

Citocromo P-450 CYP11B2; Fadrozol; Ratos; Animais; Camundongos; Fadrozol/toxicidade; Aldosterona; Ratos Sprague-Dawley; Doença Iatrogênica; Inflamação/induzido quimicamente; Colo

Palavras-chave

CYP11B2; aldosterone synthase inhibitor FAD286; extra-adrenal aldosterone; intestinal aldosterone synthesis; intestinal inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fadrozol / Citocromo P-450 CYP11B2 Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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