Jobelyn® improves motor dysfunctions induced by haloperidol in mice via neuroprotective mechanisms relating to modulation of cAMP response-element binding protein and mitogen-activated protein kinase.

Umukoro, Solomon; Ajayi, Abayomi Mayowa; Ben-Azu, Benneth; Ademola, Adeleke Pual; Areelu, Jacob; Orji, Chika; Okubena, Olajuwon

Umukoro, Solomon; Ajayi, Abayomi Mayowa; Ben-Azu, Benneth; Ademola, Adeleke Pual; Areelu, Jacob; Orji, Chika; Okubena, Olajuwon.

Afiliação

Umukoro S; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Sango-Ojo Road, Ibadan, Oyo State, Nigeria. umusolo@yahoo.com.
Ajayi AM; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Sango-Ojo Road, Ibadan, Oyo State, Nigeria.
Ben-Azu B; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Sango-Ojo Road, Ibadan, Oyo State, Nigeria.
Ademola AP; Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta University, Abraka, Nigeria.
Areelu J; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Sango-Ojo Road, Ibadan, Oyo State, Nigeria.
Orji C; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Sango-Ojo Road, Ibadan, Oyo State, Nigeria.
Okubena O; Neuropharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Sango-Ojo Road, Ibadan, Oyo State, Nigeria.

Metab Brain Dis ; 38(7): 2269-2280, 2023 10.

Article em En | MEDLINE | ID: mdl-37347426

Assuntos

Antioxidantes; Haloperidol; Animais; Masculino; Camundongos; Antioxidantes/metabolismo; Antioxidantes/farmacologia; Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico/metabolismo; Citocinas; Haloperidol/farmacologia; Proteínas Quinases Ativadas por Mitógeno

Palavras-chave

CREB and MAPK pathways; Haloperidol; Jobelyn®; Parkinsonian-like motor symptoms

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Haloperidol / Antioxidantes Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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