Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers.

Jeong, Angela; Pastor, Catherine M; Brouwer, Kim L R

Jeong, Angela; Pastor, Catherine M; Brouwer, Kim L R.

Afiliação

Jeong A; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 100 L Beard Hall, CB# 7569, Chapel Hill, NC, 27599-7569, USA.
Pastor CM; Centre de recherche sur l'inflammation, Université de Paris, Inserm, U1149, CNRS, ERL8252, F-75006, Paris, France.
Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 100 L Beard Hall, CB# 7569, Chapel Hill, NC, 27599-7569, USA. kbrouwer@unc.edu.

Pharm Res ; 40(11): 2513-2523, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37349653

Assuntos

Fígado; Compostos Organometálicos; Ratos; Animais; Fígado/diagnóstico por imagem; Fígado/metabolismo; Hepatócitos; Compostos Organometálicos/farmacocinética; Bile; Transporte Biológico

Palavras-chave

hepatobiliary imaging; isolated perfused rat liver; pharmacokinetics; transporters

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Fígado Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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