NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice.
Nat Commun
; 14(1): 3804, 2023 06 26.
Article
em En
| MEDLINE
| ID: mdl-37365163
ABSTRACT
The interleukin-1 family members, IL-1ß and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1ß processing in myeloid cells have been defined, those involved in IL-18 processing, particularly in non-myeloid cells, are still not well understood. Here we report that the host defence molecule NOD1 regulates IL-18 processing in mouse epithelial cells in response to the mucosal pathogen, Helicobacter pylori. Specifically, NOD1 in epithelial cells mediates IL-18 processing and maturation via interactions with caspase-1, instead of the canonical inflammasome pathway involving RIPK2, NF-κB, NLRP3 and ASC. NOD1 activation and IL-18 then help maintain epithelial homoeostasis to mediate protection against pre-neoplastic changes induced by gastric H. pylori infection in vivo. Our findings thus demonstrate a function for NOD1 in epithelial cell production of bioactive IL-18 and protection against H. pylori-induced pathology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Helicobacter
/
Interleucina-18
/
Células Epiteliais
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Proteína Adaptadora de Sinalização NOD1
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article