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In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting.
Tu, Wen Juan; Melino, Michelle; Dunn, Jenny; McCuaig, Robert D; Bielefeldt-Ohmann, Helle; Tsimbalyuk, Sofiya; Forwood, Jade K; Ahuja, Taniya; Vandermeide, John; Tan, Xiao; Tran, Minh; Nguyen, Quan; Zhang, Liang; Nam, Andy; Pan, Liuliu; Liang, Yan; Smith, Corey; Lineburg, Katie; Nguyen, Tam H; Sng, Julian D J; Tong, Zhen Wei Marcus; Chew, Keng Yih; Short, Kirsty R; Le Grand, Roger; Seddiki, Nabila; Rao, Sudha.
Afiliação
  • Tu WJ; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Melino M; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Dunn J; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • McCuaig RD; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Bielefeldt-Ohmann H; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Tsimbalyuk S; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia.
  • Forwood JK; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2678, Australia.
  • Ahuja T; School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW, 2678, Australia.
  • Vandermeide J; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Tan X; Gene Regulation and Translational Medicine Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Tran M; Genomics and Machine Learning Lab, Division of Genetics and Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.
  • Nguyen Q; Genomics and Machine Learning Lab, Division of Genetics and Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.
  • Zhang L; Genomics and Machine Learning Lab, Division of Genetics and Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, 4072, Australia.
  • Nam A; NanoString Technologies Inc., Seattle, WA, 98109, USA.
  • Pan L; NanoString Technologies Inc., Seattle, WA, 98109, USA.
  • Liang Y; NanoString Technologies Inc., Seattle, WA, 98109, USA.
  • Smith C; NanoString Technologies Inc., Seattle, WA, 98109, USA.
  • Lineburg K; Translational and Human Immunology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Nguyen TH; Translational and Human Immunology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Sng JDJ; Flow and Imaging Facility, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  • Tong ZWM; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Chew KY; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Short KR; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Le Grand R; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
  • Seddiki N; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, QLD, Australia.
  • Rao S; Université Paris-Saclay, INSERM U1184, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial diseases (IMVA-HB/IDMIT), Fontenay-aux-Roses, France.
Nat Commun ; 14(1): 3680, 2023 06 27.
Article em En | MEDLINE | ID: mdl-37369668
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article