Heme-Induced Macrophage Phenotype Switching and Impaired Endogenous Opioid Homeostasis Correlate with Chronic Widespread Pain in HIV.

Chatterjee, Tanima; Arora, Itika; Underwood, Lilly B; Lewis, Terry L; Masjoan Juncos, Juan Xavier; Heath, Sonya L; Goodin, Burel R; Aggarwal, Saurabh

Chatterjee, Tanima; Arora, Itika; Underwood, Lilly B; Lewis, Terry L; Masjoan Juncos, Juan Xavier; Heath, Sonya L; Goodin, Burel R; Aggarwal, Saurabh.

Afiliação

Chatterjee T; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, PBMR 230, 901 19th Street South, Birmingham, AL 35205, USA.
Arora I; Division of Developmental Biology and the Reproductive Sciences Center, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
Underwood LB; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, PBMR 230, 901 19th Street South, Birmingham, AL 35205, USA.
Lewis TL; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, PBMR 230, 901 19th Street South, Birmingham, AL 35205, USA.
Masjoan Juncos JX; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, PBMR 230, 901 19th Street South, Birmingham, AL 35205, USA.
Heath SL; Division of Infectious Disease, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Goodin BR; Washington University Pain Center, Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO 63130, USA.
Aggarwal S; Department of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine, PBMR 230, 901 19th Street South, Birmingham, AL 35205, USA.

Cells ; 12(12)2023 06 06.

Article em En | MEDLINE | ID: mdl-37371035

Assuntos

Infecções por HIV; Heme; Camundongos; Animais; Heme/metabolismo; Analgésicos Opioides; Hemólise; beta-Endorfina/metabolismo; Receptor 4 Toll-Like/metabolismo; Qualidade de Vida; Macrófagos/metabolismo; Dor/metabolismo; Fenótipo; Homeostase; Infecções por HIV/complicações; Infecções por HIV/metabolismo

Palavras-chave

HIV; cell-free heme; chronic widespread pain; macrophage phenotype; toll-like receptor-4; ß-endorphin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Heme Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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