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Putting transcriptional brakes on fibrosis: a negative regulator of TGFß signaling.
Rohil, Ayanna; Talekar, Siddhi; Shammas, Khalid M; Ajay, Amrendra K.
Afiliação
  • Rohil A; Renal Division Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Talekar S; Renal Division Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Shammas KM; Renal Division Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Ajay AK; Renal Division Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: akajay@bwh.harvard.edu.
Trends Cell Biol ; 33(9): 734-735, 2023 Sep.
Article em En | MEDLINE | ID: mdl-37380582
Due to the pleiotropic effect of transforming growth factor ß (TGFß) signaling inhibition, function-specific targeted inhibition of TGFß signaling is required. In a recent study, Yang et al. found that Krüppel-like factor (KLF)-13 acts as a negative regulator of TGFß. Thus, activating KLF13 in fibrotic tissues may protect them from fibrosis by decreasing TGFß signaling.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article