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EUS-guided gallbladder drainage using a lumen-apposing metal stent as rescue treatment for malignant distal biliary obstruction: a large multicenter experience.
Binda, Cecilia; Anderloni, Andrea; Fugazza, Alessandro; Amato, Arnaldo; de Nucci, Germana; Redaelli, Alessandro; Di Mitri, Roberto; Cugia, Luigi; Pollino, Valeria; Macchiarelli, Raffaele; Mangiavillano, Benedetto; Forti, Edoardo; Brancaccio, Mario Luciano; Badas, Roberta; Maida, Marcello; Sinagra, Emanuele; Repici, Alessandro; Fabbri, Carlo; Tarantino, Ilaria.
Afiliação
  • Binda C; Gastroenterology and Digestive Endoscopy Unit, Forlì-Cesena Hospitals, AUSL Romagna, Forlì-Cesena, Italy. Electronic address: cecilia.binda@gmail.com.
  • Anderloni A; Gastroenterology and Digestive Endoscopy Unit, Fondazione IRCCS, Policlinico San Matteo, Pavia, Italy.
  • Fugazza A; Digestive Endoscopy Unit, Humanitas Clinical and Research Center IRCCS, Milan, Italy.
  • Amato A; Digestive Endoscopy and Gastroenterology Department, Manzoni Hospital, ASST Lecco, Lecco, Italy.
  • de Nucci G; Gastroenterology and Endoscopy Unit, ASST Rhodense, Milan, Italy.
  • Redaelli A; Endoscopy Unit, San Gerardo Hospital, Monza, Italy.
  • Di Mitri R; Gastroenterology and Endoscopy Unit, ARNAS Civico Hospital, Palermo, Italy.
  • Cugia L; Division of Gastroenterology and Digestive Endoscopy, Department of Emergency, Azienda Ospedaliero Universitaria Sassari, Sassari, Italy.
  • Pollino V; Digestive Endoscopy Unit, S. Michele Hospital, Cagliari, Italy.
  • Macchiarelli R; Gastroenterology Unit, AOUS Policlinico S. Maria alle Scotte, Siena, Italy.
  • Mangiavillano B; Gastrointestinal Endoscopy Unit, Humanitas Mater Domini, Castellanza, Italy.
  • Forti E; Digestive and Interventional Endoscopy Unit, Ospedale Ca' Granda Niguarda, Milan, Italy.
  • Brancaccio ML; Division of Gastroenterology, S. Maria delle Croci Hospital, Ravenna, Italy.
  • Badas R; Digestive Endoscopy Unit, University Hospital, Cagliari, Italy.
  • Maida M; Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, Caltanissetta, Italy.
  • Sinagra E; Gastroenterology and Endoscopy Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
  • Repici A; Digestive Endoscopy Unit, Humanitas Clinical and Research Center IRCCS, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy.
  • Fabbri C; Gastroenterology and Digestive Endoscopy Unit, Forlì-Cesena Hospitals, AUSL Romagna, Forlì-Cesena, Italy.
  • Tarantino I; Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Palermo, Italy.
Gastrointest Endosc ; 98(5): 765-773, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37392954
BACKGROUND AND AIMS: EUS-guided gallbladder drainage (EUS-GBD) with lumen-apposing metal stents (LAMSs) has been reported as a rescue treatment with encouraging results for the relief of jaundice in patients with distal malignant biliary obstruction (DMBO) and after failure of both ERCP and EUS-guided choledochoduodenostomy. METHODS: This was a multicenter retrospective analysis of all cases of consecutive EUS-GBD with LAMSs used as a rescue treatment for patients with DMBO in 14 Italian centers from June 2015 to June 2020. Primary endpoints were technical and clinical success, whereas the secondary endpoint was the adverse event (AE) rate. RESULTS: Forty-eight patients (52.1% women) with a mean age of 74.3 ± 11.7 years were included in the study. Biliary stricture was related to pancreatic adenocarcinoma (85.4%), duodenal adenocarcinoma (2.1%), cholangiocarcinoma (4.2%), ampullary cancer (2.1%), colon cancer (4.2%), and metastatic breast cancer (2.1%). The mean diameter of the common bile duct was 13.3 ± 2.8 mm. LAMSs were placed transgastrically in 58.3% of cases and transduodenally in 41.7%. Technical success was 100%, whereas clinical success was 81.3%, with a mean total bilirubin reduction after 2 weeks of 66.5%. The mean procedure time was 26.4 minutes, and the mean hospital stay was 9.2 ± 8.2 days. AEs occurred in 5 patients (10.4%): 3 were classified as intraprocedural and 2 were classified as delayed because they occurred after >15 days. When the American Society for Gastrointestinal Endoscopy lexicon was used, 2 AEs were mild and 3 were moderate (2 buried LAMSs). The mean follow-up was 122 days. CONCLUSIONS: Our study shows that EUS-GBD with LAMSs used as a rescue treatment for patients affected by DMBO represents a valuable option in terms of technical and clinical success rates, with an acceptable AE rate. To the best of our knowledge, this is the largest study concerning the use of this procedure. (Clinical trial registration number: NCT03903523.).
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Ampola Hepatopancreática / Adenocarcinoma / Colestase / Neoplasias do Ducto Colédoco Tipo de estudo: Clinical_trials Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Ampola Hepatopancreática / Adenocarcinoma / Colestase / Neoplasias do Ducto Colédoco Tipo de estudo: Clinical_trials Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article