A biomechanics-based parametrized cardiac end-diastolic pressure-volume relationship for accurate patient-specific calibration and estimation.
Sci Rep
; 13(1): 11232, 2023 07 11.
Article
em En
| MEDLINE
| ID: mdl-37433813
ABSTRACT
A simple power law has been proposed in the pioneering work of Klotz et al. (Am J Physiol Heart Circ Physiol 291(1)H403-H412, 2006) to approximate the end-diastolic pressure-volume relationship of the left cardiac ventricle, with limited inter-individual variability provided the volume is adequately normalized. Nevertheless, we use here a biomechanical model to investigate the sources of the remaining data dispersion observed in the normalized space, and we show that variations of the parameters of the biomechanical model realistically account for a substantial part of this dispersion. We therefore propose an alternative law based on the biomechanical model that embeds some intrinsic physical parameters, which directly enables personalization capabilities, and paves the way for related estimation approaches.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pacientes
/
Ventrículos do Coração
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article