SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis.
Eur Respir Rev
; 32(169)2023 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-37437914
ABSTRACT
BACKGROUND:
Many individuals hospitalised with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection experience post-acute sequelae of SARS-CoV-2 infection (PASC), sometimes referred to as "long COVID". Our objective was to conduct a systematic literature review and meta-analysis to identify PASC-associated symptoms in previously hospitalised patients and determine the frequency and temporal nature of PASC.METHODS:
Searches of MEDLINE, Embase, Cochrane Library (2019-2021), World Health Organization International Clinical Trials Registry Platform and reference lists were performed from November to December 2021. Articles were assessed by two reviewers against eligibility criteria and a risk of bias tool. Symptom data were synthesised by random effects meta-analyses.RESULTS:
Of 6942 records, 52 studies with at least 100 patients were analysed; â¼70% were Europe-based studies. Most data were from the first wave of the pandemic. PASC symptoms were analysed from 28â days after hospital discharge. At 1-4â months post-acute SARS-CoV-2 infection, the most frequent individual symptoms were fatigue (29.3% (95% CI 20.1-40.6%)) and dyspnoea (19.6% (95% CI 12.8-28.7%)). Many patients experienced at least one symptom at 4-8â months (73.1% (95% CI 44.2-90.3%)) and 8-12â months (75.0% (95% CI 56.4-87.4%)).CONCLUSIONS:
A wide spectrum of persistent PASC-associated symptoms were reported over the 1-year follow-up period in a significant proportion of participants. Further research is needed to better define PASC duration and determine whether factors such as disease severity, vaccination and treatments have an impact on PASC.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
SARS-CoV-2
/
COVID-19
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article