Genetic inactivation of the Carnitine/Acetyl-Carnitine mitochondrial carrier of Yarrowia lipolytica leads to enhanced odd-chain fatty acid production.

Messina, Eugenia; de Souza, Camilla Pires; Cappella, Claudia; Barile, Simona Nicole; Scarcia, Pasquale; Pisano, Isabella; Palmieri, Luigi; Nicaud, Jean-Marc; Agrimi, Gennaro

Messina, Eugenia; de Souza, Camilla Pires; Cappella, Claudia; Barile, Simona Nicole; Scarcia, Pasquale; Pisano, Isabella; Palmieri, Luigi; Nicaud, Jean-Marc; Agrimi, Gennaro.

Afiliação

Messina E; Department of Biosciences, Biotechnology and Environment, University of Bari "Aldo Moro", Campus Universitario, via Orabona 4, Bari, 70125, Italy.
de Souza CP; Université Paris-Saclay, INRAE, Micalis Institute, Jouy-en-Josas, 78350, AgroParisTech, France.
Cappella C; Université Paris-Saclay, INRAE, Micalis Institute, Jouy-en-Josas, 78350, AgroParisTech, France.
Barile SN; Department of Biosciences, Biotechnology and Environment, University of Bari "Aldo Moro", Campus Universitario, via Orabona 4, Bari, 70125, Italy.
Scarcia P; Department of Biosciences, Biotechnology and Environment, University of Bari "Aldo Moro", Campus Universitario, via Orabona 4, Bari, 70125, Italy.
Pisano I; Department of Biosciences, Biotechnology and Environment, University of Bari "Aldo Moro", Campus Universitario, via Orabona 4, Bari, 70125, Italy.
Palmieri L; Department of Biosciences, Biotechnology and Environment, University of Bari "Aldo Moro", Campus Universitario, via Orabona 4, Bari, 70125, Italy.
Nicaud JM; Department of Biosciences, Biotechnology and Environment, University of Bari "Aldo Moro", Campus Universitario, via Orabona 4, Bari, 70125, Italy.
Agrimi G; Bioenergetics and Molecular Biotechnologies (IBIOM), CNR Institute of Biomembranes, Campus Universitario, via Orabona 4, Bari, 70125, Italy.

Microb Cell Fact ; 22(1): 128, 2023 Jul 13.

Article em En | MEDLINE | ID: mdl-37443049

Assuntos

Carnitina; Yarrowia; Acetilcoenzima A/metabolismo; Carnitina/metabolismo; Acetilcarnitina/metabolismo; Yarrowia/genética; Yarrowia/metabolismo; Ácidos Graxos/metabolismo; Propionatos/metabolismo; Mitocôndrias/metabolismo; Engenharia Metabólica

Palavras-chave

Acetyl-CoA; Carnitine/Acetyl-Carnitine shuttle; Metabolic engineering; Mitochondrial carrier; Odd-chain fatty acids (OCFAs); Yarrowia lipolytica

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina / Yarrowia Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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