Pyrazolo[4,3-<i>e</i>]tetrazolo[1,5-<i>b</i>][1,2,4]triazine Sulfonamides as an Important Scaffold for Anticancer Drug Discovery-In Vitro and In Silico Evaluation.

Kciuk, Mateusz; Marciniak, Beata; Celik, Ismail; Zerroug, Enfale; Dubey, Amit; Sundaraj, Rajamanikandan; Mujwar, Somdutt; Bukowski, Karol; Mojzych, Mariusz; Kontek, Renata

Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as an Important Scaffold for Anticancer Drug Discovery-In Vitro and In Silico Evaluation.

Kciuk, Mateusz; Marciniak, Beata; Celik, Ismail; Zerroug, Enfale; Dubey, Amit; Sundaraj, Rajamanikandan; Mujwar, Somdutt; Bukowski, Karol; Mojzych, Mariusz; Kontek, Renata.

Afiliação

Kciuk M; Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
Marciniak B; Doctoral School of Exact and Natural Sciences, University of Lodz, Banacha Street 12/16, 90-237 Lodz, Poland.
Celik I; Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
Zerroug E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38280, Turkey.
Dubey A; Group of Computational and Pharmaceutical Chemistry, LMCE Laboratory, University of Biskra, BP 145, Biskra 07000, Algeria.
Sundaraj R; Computational Chemistry and Drug Discovery Division, Quanta Calculus, Greater Noida 274203, Uttar Prades, India.
Mujwar S; Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India.
Bukowski K; Centre for Drug Discovery, Department of Biochemistry, Karpagam Academy of Higher Education, Coimbatore 641021, Tamil Nadu, India.
Mojzych M; Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
Kontek R; Department of Molecular Biotechnology and Genetics, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.

Int J Mol Sci ; 24(13)2023 Jun 30.

Article em En | MEDLINE | ID: mdl-37446136

Assuntos

Antineoplásicos; Triazinas; Linhagem Celular Tumoral; Triazinas/farmacologia; Sulfonamidas/farmacologia; Antineoplásicos/farmacologia; Apoptose; Caspases/metabolismo; Sulfanilamida/farmacologia; Ensaios de Seleção de Medicamentos Antitumorais; Proliferação de Células; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

apoptosis; cytotoxicity; heterocycles; pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine; sulfonamides

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triazinas / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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