LDA-1: a ubiquitous noncollagenous lamina densa component of basement membrane detected by monoclonal antibody technique.
J Invest Dermatol
; 86(3): 286-9, 1986 Mar.
Article
em En
| MEDLINE
| ID: mdl-3745953
ABSTRACT
Using monoclonal antibody technology, a new basement membrane antigen, designated as LDA-1, has been identified. This antigen is expressed in all human tissues thus far examined; within skin it is detectable not only within the dermal-epidermal junction but also within dermal vascular and appendageal basement membranes. In addition to human skin, LDA-1 is also detectable within rabbit but not monkey, rat, mouse, guinea pig, or cow skin. This antigen has been ultrastructurally localized to the lamina densa and to a much lesser extent, the adjacent sublamina densa region. ELISA (enzyme-linked immunosorbent assay) revealed no cross-reactivity between LDA-1 and type IV collagen, laminin, fibronectin, and heparan sulfate proteoglycan. In vitro enzymatic studies suggest that LDA-1 is noncollagenous in nature.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Basal
/
Anticorpos Monoclonais
/
Antígenos
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article