DUSP1 interacts with and dephosphorylates VCP to improve mitochondrial quality control against endotoxemia-induced myocardial dysfunction.

Zhu, Hang; Wang, Jin; Xin, Ting; Chen, Shanshan; Hu, Ruiying; Li, Yukun; Zhang, Mingming; Zhou, Hao

Zhu, Hang; Wang, Jin; Xin, Ting; Chen, Shanshan; Hu, Ruiying; Li, Yukun; Zhang, Mingming; Zhou, Hao.

Afiliação

Zhu H; Senior Department of Cardiology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, 100048, China.
Wang J; Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, 100144, China.
Xin T; Department of Cardiology, Tianjin First Central Hospital, 24 Fukang Road, Nankai District, Tianjin, 300192, People's Republic of China.
Chen S; Senior Department of Cardiology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, 100048, China.
Hu R; Senior Department of Cardiology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, 100048, China.
Li Y; Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Zhang M; Department of Cardiology, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, China. winterzhang3@163.com.
Zhou H; Senior Department of Cardiology, The Sixth Medical Center of People's Liberation Army General Hospital, Beijing, 100048, China. zhouhao@plagh.org.

Cell Mol Life Sci ; 80(8): 213, 2023 Jul 18.

Article em En | MEDLINE | ID: mdl-37464072

Assuntos

Cardiomiopatias; Endotoxemia; Animais; Camundongos; Cardiomiopatias/metabolismo; Fosfatase 1 de Especificidade Dupla/genética; Fosfatase 1 de Especificidade Dupla/metabolismo; Endotoxemia/induzido quimicamente; Endotoxemia/genética; Endotoxemia/complicações; Lipopolissacarídeos/metabolismo; Mitocôndrias/metabolismo; Miócitos Cardíacos/metabolismo; Proteína com Valosina/genética; Proteína com Valosina/metabolismo

Palavras-chave

Apoptosis; DUSP1; Endotoxemia-caused myocardial dysfunction; Mitochondria; Mitochondrial quality control; Myocardial inflammation; Oxidative stress; VCP

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotoxemia / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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