Evaluation of DeGIR registry data on endovascular treatment of cerebral vasospasm in Germany 2018-2021: an overview of the current care situation. / Auswertung der DeGIR-Registerdaten zur endovaskulären Therapie von zerebralen Vasospasmen in Deutschland 20182021: Ein Überblick über die aktuelle Versorgungssituation.
Rofo
; 195(11): 1018-1026, 2023 11.
Article
em En, De
| MEDLINE
| ID: mdl-37467777
ABSTRACT
BACKGROUND:
Evaluation of endovascular therapies for cerebral vasospasm (CVS) documented in the DeGIR registry from 2018-2021 to analyse the current clinical care situation in Germany.METHODS:
Retrospective analysis of the clinical and procedural data on endovascular spasm therapies (EST) documented anonymously in the DeGIR registry. We analysed pre-interventional findings of CTP and consciousness; radiation dose applied, interventional-technical parameters (local medication, devices, angiographic result), post-interventional symptoms, complications and mortality.RESULTS:
3584 patients received a total of 7628 EST (median age/patient 53 [range 13-100, IQR 44-60], 68.2â% women) in 91 (2018), 92 (2019), 100 (2020) and 98 (2021) centres; 5388 (70.6â%) anterior circulation and 378 (5â%) posterior circulation (both involved in 1862 cases [24.4â%]). EST was performed once in 2125 cases (27.9â%), with a mean of 2.1 EST/patient. In 7476 times, purely medicated EST were carried out (nimodipine 6835, papaverine 401, nitroglycerin 62, other drug not specified 239; combinations 90). Microcatheter infusions were documented in 1132 times (14.8â%). Balloon angioplasty (BA) (additional) was performed in 756 EST (9.9â%), other mechanical recanalisations in 154 cases (2â%) and stenting in 176 of the EST (2.3â%). The median dose area product during ET was 4069 cGycm² (drug 4002/[+]BA 8003 [pâ<â0.001]). At least 1 complication occurred in 95 of all procedures (1.2â%) (drug 1.1â%/[+]BA 4.2â% [pâ<â0.001]). Mortality associated with EST was 0.2â% (nâ=â18). After EST, overall improvement or elimination of CVS was found in 94.2â% of cases (drug 93.8â%/[+]BA 98.1â% [pâ<â0.001]). In a comparison of the locally applied drugs, papaverine eliminated CVS more frequently than nimodipine (pâ=â0.001).CONCLUSION:
EST have a moderate radiation exposure and can be performed with few complications. Purely medicated EST are predominantly performed, especially with nimodipine. With (additional) BA, radiation exposure, complication rates and angiographic results are higher or better. When considering drug EST alone, there is evidence for an advantage of papaverine over nimodipine, but a different group size has to be taken into account. In the analysis of EST, the DeGIR registry data are suitable for answering more specific questions, especially due to the large number of cases; for this purpose, further subgroupings should be sought in the data documentation. KEY POINTS · In Germany, there are currently no guidelines for the endovascular treatment of cerebral vasospasm following spontaneous subarachnoid hemorrhage.. · In addition to oral nimodipine administration endovascular therapy is used to treat cerebral vasospasm in most hospitals.. · This is the first systematic evaluation of nationwide registry data on endovascular treatment of cerebral vasopasm in Germany.. · This real-world data shows that endovascular treatment for cerebral vasospasm has a moderate radiation exposure and can be performed with few complications overall. With (additional) balloon angioplasty, radiation exposure, complication rates and angiographic therapy results are higher or better.. CITATION FORMAT · Neumann A, Weber W, Küchler J etâal. Evaluation of DeGIR registry data on endovascular treatment of cerebral vasospasm in Germany 2018-2021 an overview of the current care situation. Fortschr Röntgenstr 2023; 195 1018â-â1026.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemorragia Subaracnóidea
/
Vasoespasmo Intracraniano
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Procedimentos Endovasculares
Tipo de estudo:
Guideline
Limite:
Female
/
Humans
/
Male
Idioma:
De
/
En
Ano de publicação:
2023
Tipo de documento:
Article