MDM2-Targeting Reassembly Peptide (TRAP) Nanoparticles for p53-Based Cancer Therapy.

Li, Fangzhou; Chen, Delin; Sun, Qianqian; Wu, Jiale; Gan, Yaling; Leong, Kam W; Liang, Xing-Jie

Li, Fangzhou; Chen, Delin; Sun, Qianqian; Wu, Jiale; Gan, Yaling; Leong, Kam W; Liang, Xing-Jie.

Afiliação

Li F; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing, 100190, P. R. China.
Chen D; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, 10033, USA.
Sun Q; State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, 100005, P. R. China.
Wu J; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine (Shanghai), Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.
Gan Y; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing, 100190, P. R. China.
Leong KW; Department of Biomedical Engineering, Columbia University, New York, 10032, United States.
Liang XJ; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11, First North Road, Zhongguancun, Beijing, 100190, P. R. China.

Adv Mater ; 35(45): e2305164, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37474204

Assuntos

Neoplasias; Proteína Supressora de Tumor p53; Humanos; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Proteína Supressora de Tumor p14ARF/genética; Proteína Supressora de Tumor p14ARF/metabolismo; Proteínas Proto-Oncogênicas c-mdm2/genética; Proteínas Proto-Oncogênicas c-mdm2/metabolismo; Peptídeos/farmacologia; Peptídeos/metabolismo; Neoplasias/tratamento farmacológico

Palavras-chave

ARF; MDM2 trap; arsenic trioxide; cancer therapy; mutant p53; peptides; wild-type p53

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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