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Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces.
Vatsyayan, Ritwik; Lee, Jihwan; Bourhis, Andrew M; Tchoe, Youngbin; Cleary, Daniel R; Tonsfeldt, Karen J; Lee, Keundong; Montgomery-Walsh, Rhea; Paulk, Angelique C; U, Hoi Sang; Cash, Sydney S; Dayeh, Shadi A.
Afiliação
  • Vatsyayan R; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA.
  • Lee J; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA.
  • Bourhis AM; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA.
  • Tchoe Y; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA.
  • Cleary DR; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA; Department of Neurological Surgery, School of Medicine, Oregon Health & Science University, Portland, USA.
  • Tonsfeldt KJ; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA; Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California, San Di
  • Lee K; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA.
  • Montgomery-Walsh R; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA; Department of Bioengineering, University of California, San Diego, San Diego, USA.
  • Paulk AC; Department of Neurology, Harvard Medical School, Boston, USA; Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, USA.
  • U HS; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA.
  • Cash SS; Department of Neurology, Harvard Medical School, Boston, USA; Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, USA.
  • Dayeh SA; Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, San Diego, USA; Department of Bioengineering, University of California, San Diego, San Diego, USA.
MRS Bull ; 48(5): 531-546, 2023 May.
Article em En | MEDLINE | ID: mdl-37476355
ABSTRACT
Electrophysiological recording and stimulation are the gold standard for functional mapping during surgical and therapeutic interventions as well as capturing cellular activity in the intact human brain. A critical component probing human brain activity is the interface material at the electrode contact that electrochemically transduces brain signals to and from free charge carriers in the measurement system. Here, we summarize state-of-the-art electrode array systems in the context of translation for use in recording and stimulating human brain activity. We leverage parametric studies with multiple electrode materials to shed light on the varied levels of suitability to enable high signal-to-noise electrophysiological recordings as well as safe electrophysiological stimulation delivery. We discuss the effects of electrode scaling for recording and stimulation in pursuit of high spatial resolution, channel count electrode interfaces, delineating the electrode-tissue circuit components that dictate the electrode performance. Finally, we summarize recent efforts in the connectorization and packaging for high channel count electrode arrays and provide a brief account of efforts toward wireless neuronal monitoring systems.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article