[Chromosomal structural abnormalities in men with semen abnormality and analysis of 19 cases of first-reported abnormal karyotype].
Zhonghua Nan Ke Xue
; 28(5): 402-407, 2022 May.
Article
em Zh
| MEDLINE
| ID: mdl-37477478
ABSTRACT
OBJECTIVE:
To investigate the chromosomal structural abnormalities and pregnancy outcomes in men with semen abnormality.METHODS:
We analyzed the karyotype of 3 095 male patients with semen abnormality spermatogenesis, performed pedigree analysis and provided reproduction guidance for those with chromosomal structural abnormalities.RESULTS:
Of the 3 095 male patients with semen abnormality, 52 (1.68%) cases of chromosomal structural abnormalities were detected, including 28 cases of balanced translocation, 21 cases of Robertsonian translocation and 3 cases of chromosome inversion. There were 19 cases of rare abnormal karyotype first reported in the world.CONCLUSION:
Reciprocal translocation is a main type of chromosomal structural abnormality in male patients with semen abnormality. An insight into the types of chromosomal abnormalities and analysis of the heredity of chromosomes in a family may help detect chromosomal abnormality carriers and provide scientific reproduction guidance.Palavras-chave
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sêmen
/
Aberrações Cromossômicas
Limite:
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
Zh
Ano de publicação:
2022
Tipo de documento:
Article