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Investigation of the color discrimination ability using the Farnsworth-Munsell 100-hue test and structural changes by SS-OCT in patients with transfusion-dependent beta-thalassemia.
Koctekin, Belkis; Dogan, Berna; Erdem, Ramazan; Buber, Hakan; Kurtoglu, Erdal; Karakus, Volkan.
Afiliação
  • Koctekin B; University of Health Sciences, Antalya Training and Research Hospital, Transfusion Center, Antalya, Turkey. Electronic address: bkoctekin@gmail.com.
  • Dogan B; University of Health Sciences, Antalya Training and Research Hospital, Department of Ophthalmology, Antalya, Turkey.
  • Erdem R; University of Health Sciences, Antalya Training and Research Hospital, Department of Hematology, Antalya, Turkey.
  • Buber H; University of Health Sciences, Antalya Training and Research Hospital, Department of Ophthalmology, Antalya, Turkey.
  • Kurtoglu E; Kolan Hospital Group, Sisli Kolan International Department of Hematology, Istanbul, Turkey.
  • Karakus V; University of Health Sciences, Antalya Training and Research Hospital, Department of Hematology, Antalya, Turkey.
Photodiagnosis Photodyn Ther ; 43: 103716, 2023 Sep.
Article em En | MEDLINE | ID: mdl-37481147
AIM: This study aimed to examine the color discrimination ability of patients with transfusion-dependent beta-thalassemia (TDß-T) in detail using the Farnsworth Munsell (FM) 100-hue test and to evaluate structural changes by swept source-optical coherence tomography (SS-OCT). MATERIAL AND METHODS: This prospective, sectional study included 40 patients (79 eyes) with TDß-T and 21 controls (42 eyes). The volunteers underwent a detailed ophthalmological examination and SS-OCT (DRI-OCT, Triton) imaging. Excluded were those with congenital color vision defects detected with the Ishihara pseudoisochromatic test. The patients' color vision was examined using the FM 100-hue test. The total error score (TES), the blue-yellow local error score (b-y LES), and the red-green local error score (r-g LES) were calculated. p <0.05 was considered significant. RESULTS: The mean age was 30.34±6.94 years in the patient group and 32.26±6.43 years in the control group (p = 0.078). The patient group had a significantly lower hemoglobin level (9.25±0.87 g/dL vs. 14±1.79 g/dL, p <0.001) and a significantly higher ferritin level (2665.56±2658.05 µg/L vs. 52.87±69.59 µg/L, p<0.001) compared to the control group. The mean TES, b-y LES, and r-g LES were higher in the patients than in the controls (64.84±30.18 vs. 28.45±16.55, p<0.001, 34.21±17.54 vs. 15.67±10.07, p <0.001, and 29.32±15.72 vs. 12.12±7.94, p<0.001, respectively). The patients had a higher b-y LES than r-g LES (34.21±17.54 vs. 29.32±15.72, p = 0.015). Choroidal thickness was lower in the patients than in the controls (284.34±63.55 µm vs. 324.98±88.05 µm, p = 0.043). CONCLUSION: We found that the color discrimination ability of the patients with TDß-T was reduced in both the r-g and b-y color axes compared to the controls, and their color discrimination ability in the b-y color axis was more affected than in the r-g axis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Talassemia beta Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Talassemia beta Tipo de estudo: Observational_studies / Prognostic_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article