LAG-3 as the third checkpoint inhibitor.
Nat Immunol
; 24(9): 1415-1422, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37488429
ABSTRACT
Lymphocyte activation gene 3 (LAG-3) is an inhibitory receptor that is highly expressed by exhausted T cells. LAG-3 is a promising immunotherapeutic target, with more than 20 LAG-3-targeting therapeutics in clinical trials and a fixed-dose combination of anti-LAG-3 and anti-PD-1 now approved to treat unresectable or metastatic melanoma. Although LAG-3 is widely recognized as a potent inhibitory receptor, important questions regarding its biology and mechanism of action remain. In this Perspective, we focus on gaps in the understanding of LAG-3 biology and discuss the five biggest topics of current debate and focus regarding LAG-3, including its ligands, signaling and mechanism of action, its cell-specific functions, its importance in different disease settings, and the development of novel therapeutics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína do Gene 3 de Ativação de Linfócitos
/
Melanoma
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article