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Randomized placebo-controlled crossover study to assess tolerability and pharmacodynamics of zagociguat, a soluble guanylyl cyclase stimulator, in healthy elderly.
van Kraaij, Sebastiaan J W; Borghans, Laura; Klaassen, Erica S; Gal, Pim; van der Grond, Jeroen; Tripp, Ken; Winrow, Christopher; Glasser, Chad; Groeneveld, Geert Jan.
Afiliação
  • van Kraaij SJW; Centre for Human Drug Research, Leiden, The Netherlands.
  • Borghans L; Department of Surgery, Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Klaassen ES; Centre for Human Drug Research, Leiden, The Netherlands.
  • Gal P; Centre for Human Drug Research, Leiden, The Netherlands.
  • van der Grond J; Centre for Human Drug Research, Leiden, The Netherlands.
  • Tripp K; Department of Surgery, Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Winrow C; Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
  • Glasser C; Cyclerion Therapeutics, Cambridge, Massachusetts, USA.
  • Groeneveld GJ; Cyclerion Therapeutics, Cambridge, Massachusetts, USA.
Br J Clin Pharmacol ; 89(12): 3606-3617, 2023 12.
Article em En | MEDLINE | ID: mdl-37488930
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Guanosina Monofosfato / Óxido Nítrico Tipo de estudo: Clinical_trials Limite: Aged / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Guanosina Monofosfato / Óxido Nítrico Tipo de estudo: Clinical_trials Limite: Aged / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article