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Protein target highlights in CASP15: Analysis of models by structure providers.
Alexander, Leila T; Durairaj, Janani; Kryshtafovych, Andriy; Abriata, Luciano A; Bayo, Yusupha; Bhabha, Gira; Breyton, Cécile; Caulton, Simon G; Chen, James; Degroux, Séraphine; Ekiert, Damian C; Erlandsen, Benedikte S; Freddolino, Peter L; Gilzer, Dominic; Greening, Chris; Grimes, Jonathan M; Grinter, Rhys; Gurusaran, Manickam; Hartmann, Marcus D; Hitchman, Charlie J; Keown, Jeremy R; Kropp, Ashleigh; Kursula, Petri; Lovering, Andrew L; Lemaitre, Bruno; Lia, Andrea; Liu, Shiheng; Logotheti, Maria; Lu, Shuze; Markússon, Sigurbjörn; Miller, Mitchell D; Minasov, George; Niemann, Hartmut H; Opazo, Felipe; Phillips, George N; Davies, Owen R; Rommelaere, Samuel; Rosas-Lemus, Monica; Roversi, Pietro; Satchell, Karla; Smith, Nathan; Wilson, Mark A; Wu, Kuan-Lin; Xia, Xian; Xiao, Han; Zhang, Wenhua; Zhou, Z Hong; Fidelis, Krzysztof; Topf, Maya; Moult, John.
Afiliação
  • Alexander LT; Biozentrum, University of Basel, Basel, Switzerland.
  • Durairaj J; Computational Structural Biology, SIB Swiss Institute of Bioinformatics, Basel, Switzerland.
  • Kryshtafovych A; Biozentrum, University of Basel, Basel, Switzerland.
  • Abriata LA; Computational Structural Biology, SIB Swiss Institute of Bioinformatics, Basel, Switzerland.
  • Bayo Y; Genome Center, University of California, Davis, Davis, California, USA.
  • Bhabha G; School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Breyton C; Department of Biosciences, University of Milano, Milan, Italy.
  • Caulton SG; IBBA-CNR Unit of Milano, Institute of Agricultural Biology and Biotechnology, Milan, Italy.
  • Chen J; Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
  • Degroux S; Univ. Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
  • Ekiert DC; The University of Birmingham, Birmingham, UK.
  • Erlandsen BS; Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
  • Freddolino PL; Univ. Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
  • Gilzer D; Department of Cell Biology, New York University School of Medicine, New York, New York, USA.
  • Greening C; Department of Microbiology, New York University School of Medicine, New York, New York, USA.
  • Grimes JM; Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh, UK.
  • Grinter R; Department of Biological Chemistry, Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.
  • Gurusaran M; Department of Chemistry, Bielefeld University, Bielefeld, Germany.
  • Hartmann MD; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Hitchman CJ; Securing Antarctica's Environmental Future, Monash University, Clayton, Victoria, Australia.
  • Keown JR; Centre to Impact AMR, Monash University, Clayton, Victoria, Australia.
  • Kropp A; ARC Research Hub for Carbon Utilisation and Recycling, Monash University, Clayton, Victoria, Australia.
  • Kursula P; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Lovering AL; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Lemaitre B; Centre for Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia.
  • Lia A; Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh, UK.
  • Liu S; Max Planck Institute for Biology, Tübingen, Germany.
  • Logotheti M; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
  • Lu S; Department of Molecular and Cell Biology, Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, UK.
  • Markússon S; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Miller MD; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
  • Minasov G; Department of Biomedicine, University of Bergen, Bergen, Norway.
  • Niemann HH; Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, Oulu, Finland.
  • Opazo F; The University of Birmingham, Birmingham, UK.
  • Phillips GN; School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Davies OR; Department of Molecular and Cell Biology, Leicester Institute of Structural and Chemical Biology, University of Leicester, Leicester, UK.
  • Rommelaere S; ISPA-CNR Unit of Lecce, Institute of Sciences of Food Production, Lecce, Italy.
  • Rosas-Lemus M; Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.
  • Roversi P; California NanoSystems Institute, University of California, Los Angeles, California, USA.
  • Satchell K; Max Planck Institute for Biology, Tübingen, Germany.
  • Smith N; Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany.
  • Wilson MA; Lanzhou University School of Life Sciences, Lanzhou, China.
  • Wu KL; Department of Biomedicine, University of Bergen, Bergen, Norway.
  • Xia X; Department of Biosciences, Rice University, Houston, Texas, USA.
  • Xiao H; Department of Microbiology-Immunology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA.
  • Zhang W; Department of Chemistry, Bielefeld University, Bielefeld, Germany.
  • Zhou ZH; NanoTag Biotechnologies GmbH, Göttingen, Germany.
  • Fidelis K; Institute of Neuro- and Sensory Physiology, University of Göttingen Medical Center, Göttingen, Germany.
  • Topf M; Center for Biostructural Imaging of Neurodegeneration (BIN), University of Göttingen Medical Center, Göttingen, Germany.
  • Moult J; Department of Biosciences, Rice University, Houston, Texas, USA.
Proteins ; 91(12): 1571-1599, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37493353
ABSTRACT
We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Biologia Computacional Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Biologia Computacional Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article