Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases.
J Biol Chem
; 299(9): 105089, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37495112
ABSTRACT
Recent discoveries establish tRNAs as central regulators of mRNA translation dynamics, and therefore cotranslational folding and function of the encoded protein. The tRNA pool, whose composition and abundance change in a cell- and tissue-dependent manner, is the main factor which determines mRNA translation velocity. In this review, we discuss a group of pathogenic mutations, in the coding sequences of either protein-coding genes or in tRNA genes, that alter mRNA translation dynamics. We also summarize advances in tRNA biology that have uncovered how variations in tRNA levels on account of genetic mutations affect protein folding and function, and thereby contribute to phenotypic diversity in clinical manifestations.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
RNA Mensageiro
/
RNA de Transferência
/
Mutação
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article