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Safety and Tolerability of Direct Ischemic Postconditioning Following Thrombectomy for Acute Ischemic Stroke.
Wu, Longfei; Wei, Ming; Zhang, Bohao; Zhang, Bowei; Chen, Jian; Wang, Sifei; Luo, Leilei; Liu, Shuling; Li, Sijie; Ren, Changhong; Hess, David C; Song, Haiqing; Zhao, Wenbo; Ji, Xunming.
Afiliação
  • Wu L; Department of Neurology, Xuanwu Hospital (L.W., Bowei Zhang, H.S., W.Z.), Capital Medical University, Beijing, China.
  • Wei M; Beijing Institute for Brain Disorders (M.W.), Capital Medical University, Beijing, China.
  • Zhang B; Department of Neurosurgery (M.W., S.W., S. Liu), Tianjin Huanhu Hospital, China.
  • Zhang B; Tianjin University, China (M.W.).
  • Chen J; Department of Neurology (Bohao Zhang, L.L.), Tianjin Huanhu Hospital, China.
  • Wang S; Department of Neurology, Xuanwu Hospital (L.W., Bowei Zhang, H.S., W.Z.), Capital Medical University, Beijing, China.
  • Luo L; Department of Neurosurgery, Xuanwu Hospital (J.C., X.J.), Capital Medical University, Beijing, China.
  • Liu S; Department of Neurosurgery (M.W., S.W., S. Liu), Tianjin Huanhu Hospital, China.
  • Li S; Department of Neurology (Bohao Zhang, L.L.), Tianjin Huanhu Hospital, China.
  • Ren C; Department of Neurosurgery (M.W., S.W., S. Liu), Tianjin Huanhu Hospital, China.
  • Hess DC; Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital (S. Li, C.R.), Capital Medical University, Beijing, China.
  • Song H; Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital (S. Li, C.R.), Capital Medical University, Beijing, China.
  • Zhao W; Department of Neurology, Medical College of Georgia, Augusta University (D.C.H.).
  • Ji X; Department of Neurology, Xuanwu Hospital (L.W., Bowei Zhang, H.S., W.Z.), Capital Medical University, Beijing, China.
Stroke ; 54(9): 2442-2445, 2023 09.
Article em En | MEDLINE | ID: mdl-37497674
BACKGROUND: Experimental studies have demonstrated the neuroprotection of ischemic postconditioning (IPostC) in acute ischemic stroke by attenuating ischemia-reperfusion injury. This study aimed to investigate the safety and tolerability of direct IPostC in both a dog model and patients with acute ischemic stroke treated with thrombectomy. METHODS: The study involved 2 parts. First, IPostC was induced by repeated balloon inflation and deflation in dogs, where a low-pressure balloon was navigated to the anterior spinal artery, and 4 cycles of 5-minute ischemia followed by 5-minute reperfusion were performed. Vascular injuries were assessed using angiography and vascular tissue specimens. Then, a 3+3 dose-escalation trial was conducted in patients with acute ischemic stroke following successful thrombectomy recanalization. Patients received direct IPostC with ischemia and reperfusion durations in progressive increments of 0, 1, 2, 3, 4, and 5 minutes ×4 cycles. Major adverse responses were defined as vessel perforation, rupture, dissection, reocclusion, severe vasospasm, thrombotic events, and rupture of the balloon. RESULTS: IPostC was investigated in 4 dogs. No vessel perforation or rupture, dissection, or vasospasm was observed under the angiography. Only 1 vessel experienced mild injury between the intima and the internal elastic membrane detected on a histopathologic slide. Then, 18 patients were recruited. The duration of IPostC was progressively escalated with no major response happened. No patient experienced agitation, discomfort, or other tolerability issues. Five patients (27.8%) experienced any intracranial hemorrhage after thrombectomy, and 1 (5.6%) was symptomatic. At 3-month follow-up, no patient died, and 9 patients (50%) achieved functional independence. CONCLUSIONS: Direct IPostC inducing by 4 cycles of 5-minute ischemia followed by 5-minute reperfusion is safe, feasible, and tolerable in patients with acute ischemic stroke treated with thrombectomy. Further investigations are needed to determine the safety and preliminary efficacy of direct IPostC. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT05153655.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Isquemia Encefálica / Acidente Vascular Cerebral / Pós-Condicionamento Isquêmico / AVC Isquêmico Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Isquemia Encefálica / Acidente Vascular Cerebral / Pós-Condicionamento Isquêmico / AVC Isquêmico Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article