p63 immunoexpression in hair follicles of normal and alopecia X-affected skin of Pomeranian dogs.
Vet Dermatol
; 34(6): 567-575, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37518946
ABSTRACT
BACKGROUND:
Alopecia X in Pomeranians is caused by a hair cycle deregulation, associated with downregulation of key regulatory genes of the Wnt and Shh pathways, and stem-cell markers. However, the pathogenesis remains unclear. p63 is an important transcription factor correlated with the aforementioned hair cycle modulating genes. HYPOTHESIS/OBJECTIVES:
The aim of this study was to highlight possible changes of p63 immunohistochemical expression within the hair follicles in canine alopecia X compared with normal skin. ANIMALS Skin biopsies from 19 alopecia X-affected and six control Pomeranians were analysed. MATERIALS ANDMETHODS:
Serial histological sections of skin biopsies harbouring anagen, telogen and kenogen hair follicles were immunohistochemically evaluated for differences in p63 expression in the affected and control samples.RESULTS:
Dogs with alopecia X had a significantly decreased immunoexpression of p63 in telogen and kenogen hair follicles. CONCLUSIONS AND CLINICAL RELEVANCE The decrease of p63 immunoexpression observed in canine alopecia X suggests an involvement of p63 in hair cycle.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Folículo Piloso
/
Doenças do Cão
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article