Griseofulvin analogues from the fungus Penicillium griseofulvum and their anti-inflammatory activity.
Bioorg Chem
; 139: 106736, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37523815
ABSTRACT
Six griseofulvin analogues named penigriseofulvins A - F (1-6), including three undescribed compounds and three undescribed natural products, were isolated from the fungus Penicillium griseofulvum. Their structures and absolute configurations were determined by NMR spectroscopic analyses, HRESIMS, and X-ray diffraction experiments. All compounds were evaluated for their anti-inflammatory activity, of which compounds 1 and 4 showed potential anti-inflammatory effects in RAW264.7 macrophages and ulcerative colitis mice.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicillium
/
Griseofulvina
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article