SLC15A4 controls endolysosomal TLR7-9 responses by recruiting the innate immune adaptor TASL.

Zhang, Haobo; Bernaleau, Léa; Delacrétaz, Maeva; Hasanovic, Ed; Drobek, Ales; Eibel, Hermann; Rebsamen, Manuele

Zhang, Haobo; Bernaleau, Léa; Delacrétaz, Maeva; Hasanovic, Ed; Drobek, Ales; Eibel, Hermann; Rebsamen, Manuele.

Afiliação

Zhang H; Department of Immunobiology, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland.
Bernaleau L; Department of Immunobiology, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland.
Delacrétaz M; Department of Immunobiology, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland.
Hasanovic E; Department of Immunobiology, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland.
Drobek A; Department of Immunobiology, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland.
Eibel H; Department of Rheumatology and Clinical Immunology, Medical Center and Faculty of Medicine, University of Freiburg, Hugstetterstr. 55, 79106 Freiburg, Germany; Center for Chronic Immunodeficiency, Medical Center and Faculty of Medicine, University of Freiburg, Breisacherstr. 115, 79106 Freiburg, Ger
Rebsamen M; Department of Immunobiology, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland. Electronic address: manuele.rebsamen@unil.ch.

Cell Rep ; 42(8): 112916, 2023 08 29.

Article em En | MEDLINE | ID: mdl-37527038

Assuntos

Lúpus Eritematoso Sistêmico; Receptor 7 Toll-Like; Humanos; Receptor 7 Toll-Like/metabolismo; Receptores Toll-Like/metabolismo; Fatores Reguladores de Interferon/metabolismo; Imunidade Inata; Proteínas do Tecido Nervoso/metabolismo; Proteínas de Membrana Transportadoras/metabolismo

Palavras-chave

CP: Immunology; IRF5; SLC15A4; SLE; TASL; Toll-like receptors; autoimmunity; lysosome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 7 Toll-Like / Lúpus Eritematoso Sistêmico Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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