Your browser doesn't support javascript.
loading
Metabolic syndrome and the likelihood of knee pain and functional disability: evidence from a large middle eastern population-based study.
Ibrahim, Talal; Ahmed, Abdulaziz F; Nofal, Mariam; Hegazy, Abdelsalam; Ghomrawi, Hassan M K.
Afiliação
  • Ibrahim T; Department of Surgery, Division of Orthopaedic Surgery, Sidra Medicine, Doha, Qatar.
  • Ahmed AF; Department of Orthopaedic Surgery, Massachussetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Nofal M; Hamad Medical Corporation, Doha, Qatar.
  • Hegazy A; Department of Surgery, Division of Orthopaedic Surgery, Sidra Medicine, Doha, Qatar.
  • Ghomrawi HMK; Departments of Surgery, Medicine (Rheumatology), and Pediatrics, Northwestern University Feinberg School of Medicine, 633 N St Clair, 20th Floor, Chicago, IL, 60611, USA. hassan.ghomrawi1@northwestern.edu.
BMC Musculoskelet Disord ; 24(1): 634, 2023 Aug 04.
Article em En | MEDLINE | ID: mdl-37542219
ABSTRACT

OBJECTIVES:

Metabolic Syndrome (MetS) has been associated with knee osteoarthritis (KOA) in animal studies, but epidemiologic evidence of the association remains controversial. We investigated the association between MetS and knee pain and functional disability, the hallmarks of KOA, in a Middle Eastern population with high reported MetS rates.

METHODS:

A population-based study of adult individuals was conducted between 01/2016 and 03/2019. Data collected included age, sex, blood pressure, body mass index (BMI), waist circumference (WC), and comprehensive metabolic panel blood tests. Knee symptoms were assessed using The Western Ontario and McMaster Arthritis index (WOMAC) The Adult Treatment Panel III criteria was applied to determine if participants had MetS. Multivariable regression was used to determine the association of MetS, and its components, with the WOMAC total and subscale scores.

RESULTS:

Of 6,000 participants enrolled, 15.5% had MetS. The multivariate regression demonstrated that participants with MetS had significantly higher WOMAC total and subscale scores after adjusting for demographic variables; however, these associations were not significant after adjusting for BMI. Multivariate regression examining the association between MetS components and the WOMAC scores showed sex-based significant differences with WOMAC scores; however, the differences were not larger than the minimally clinical important differences.

CONCLUSIONS:

This study demonstrated that after adjustment for BMI, neither MetS nor its individual parameters were associated with worse knee symptoms. As such, the association between MetS and worse knee symptoms requires further study.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite do Joelho / Síndrome Metabólica Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite do Joelho / Síndrome Metabólica Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article