Clodronate is not protective in lethal viral encephalitis despite substantially reducing inflammatory monocyte infiltration in the CNS.

Spiteri, Alanna G; van Vreden, Caryn; Ashhurst, Thomas M; Niewold, Paula; King, Nicholas J C

Spiteri, Alanna G; van Vreden, Caryn; Ashhurst, Thomas M; Niewold, Paula; King, Nicholas J C.

Afiliação

Spiteri AG; Viral Immunopathology Laboratory, Infection, Immunity and Inflammation Research Theme, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
van Vreden C; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Ashhurst TM; Viral Immunopathology Laboratory, Infection, Immunity and Inflammation Research Theme, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Niewold P; Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
King NJC; Sydney Cytometry, The University of Sydney and Centenary Institute, Sydney, NSW, Australia.

Front Immunol ; 14: 1203561, 2023.

Article em En | MEDLINE | ID: mdl-37545511

Assuntos

Encefalite Viral; Febre do Nilo Ocidental; Camundongos; Animais; Monócitos; Ácido Clodrônico/farmacologia; Sistema Nervoso Central/patologia; Macrófagos; Encefalite Viral/patologia

Palavras-chave

CNS infection; bone marrow monopoiesis; clodronate; macrophage depletion; monocyte-derived cells; monocyte-mediated inflammation; neuroinflammation; virus-induced encephalitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre do Nilo Ocidental / Encefalite Viral Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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