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Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition.
Howard, Gregory C; Wang, Jing; Rose, Kristie Lindsey; Jones, Camden; Patel, Purvi; Tsui, Tina; Florian, Andrea C; Vlach, Logan; Lorey, Shelly L; Grieb, Brian C; Smith, Brianna N; Slota, Macey J; Reynolds, Elizabeth M; Goswami, Soumita; Savona, Michael R; Mason, Frank M; Lee, Taekyu; Fesik, Stephen W; Liu, Qi; Tansey, William P.
Afiliação
  • Howard GC; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Wang J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Rose KL; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
  • Jones C; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Patel P; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Tsui T; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Florian AC; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Vlach L; Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Lorey SL; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Grieb BC; Current address: Department of Biology, Belmont University, Nashville, TN 37212, USA.
  • Smith BN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Slota MJ; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Reynolds EM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Goswami S; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Savona MR; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Mason FM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Lee T; Current address: Department of Urology, University of California San Francisco, San Francisco CA 94143, USA.
  • Fesik SW; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Liu Q; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
  • Tansey WP; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
bioRxiv ; 2024 Jan 10.
Article em En | MEDLINE | ID: mdl-37546802
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article