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Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques.
Bollimpelli, Venkata S; Reddy, Pradeep B J; Gangadhara, Sailaja; Charles, Tysheena P; Burton, Samantha L; Tharp, Gregory K; Styles, Tiffany M; Labranche, Celia C; Smith, Justin C; Upadhyay, Amit A; Sahoo, Anusmita; Legere, Traci; Shiferaw, Ayalnesh; Velu, Vijayakumar; Yu, Tianwei; Tomai, Mark; Vasilakos, John; Kasturi, Sudhir P; Shaw, George M; Montefiori, David; Bosinger, Steven E; Kozlowski, Pamela A; Pulendran, Bali; Derdeyn, Cynthia A; Hunter, Eric; Amara, Rama R.
Afiliação
  • Bollimpelli VS; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Reddy PBJ; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Gangadhara S; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Charles TP; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Burton SL; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Tharp GK; NHP Genomics Core Laboratory, Emory National Primate Research Center, Atlanta, GA, 30329, USA.
  • Styles TM; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Labranche CC; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
  • Smith JC; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
  • Upadhyay AA; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Sahoo A; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Legere T; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Shiferaw A; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Velu V; Emory Vaccine Center, Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
  • Yu T; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, GA, USA.
  • Tomai M; Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA.
  • Vasilakos J; 3M Corporate Research and Materials Lab, Saint Paul, MN, USA.
  • Kasturi SP; 3M Drug Delivery Systems, Saint Paul, MN, USA.
  • Shaw GM; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, GA, USA.
  • Montefiori D; Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Bosinger SE; Department of Surgery, Duke University School of Medicine, Durham, NC, USA.
  • Kozlowski PA; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, GA, USA.
  • Pulendran B; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
  • Derdeyn CA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford University, Stanford, CA, USA.
  • Hunter E; Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, GA, USA.
  • Amara RR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Nat Commun ; 14(1): 4789, 2023 08 08.
Article em En | MEDLINE | ID: mdl-37553348
Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2 simian-human immunodeficiency virus (SHIV) challenges in female macaques. Both routes of vaccination induce comparable levels of serum IgG with neutralizing and non-neutralizing activities. The protection in MVA-ID group correlates positively with serum neutralizing and antibody-dependent phagocytic activities, and envelope-specific vaginal IgA; while the limited protection in MVA-IM group correlates only with serum neutralizing activity. MVA-ID immunizations induce greater germinal center Tfh and B cell responses, reduced the ratio of Th1 to Tfh cells in blood and showed lower activation of intermediate monocytes and inflammasome compared to MVA-IM immunizations. This lower innate activation correlates negatively with induction of Tfh responses. These data demonstrate that the MVA-ID vaccinations protect against intravaginal SHIV challenges by modulating the innate and T helper responses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacínia / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacínia / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article