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Associations of mTBI and post-traumatic stress to amygdala structure and functional connectivity in military Service Members.
Gimbel, Sarah I; Wang, Cailynn C; Hungerford, Lars; Twamley, Elizabeth W; Ettenhofer, Mark L.
Afiliação
  • Gimbel SI; Traumatic Brain Injury Center of Excellence, Silver Spring, MD, United States.
  • Wang CC; Traumatic Brain Injury Clinic, Naval Medical Center San Diego, San Diego, CA, United States.
  • Hungerford L; General Dynamics Information Technology, Falls Church, VA, United States.
  • Twamley EW; Department of Psychology, University of California, San Diego, San Diego, CA, United States.
  • Ettenhofer ML; Traumatic Brain Injury Center of Excellence, Silver Spring, MD, United States.
Front Neuroimaging ; 2: 1129446, 2023.
Article em En | MEDLINE | ID: mdl-37554633
ABSTRACT

Introduction:

Traumatic brain injury (TBI) is one of the highest public health priorities, especially among military personnel where comorbidity with post-traumatic stress symptoms and resulting consequences is high. Brain injury and post-traumatic stress symptoms are both characterized by dysfunctional brain networks, with the amygdala specifically implicated as a region with both structural and functional abnormalities.

Methods:

This study examined the structural volumetrics and resting state functional connectivity of 68 Active Duty Service Members with or without chronic mild TBI (mTBI) and comorbid symptoms of Post-Traumatic Stress (PTS). Results and

discussion:

Structural analysis of the amygdala revealed no significant differences in volume between mTBI and healthy comparison participants with and without post-traumatic stress symptoms. Resting state functional connectivity with bilateral amygdala revealed decreased anterior network connectivity and increased posterior network connectivity in the mTBI group compared to the healthy comparison group. Within the mTBI group, there were significant regions of correlation with amygdala that were modulated by PTS severity, including networks implicated in emotional processing and executive functioning. An examination of a priori regions of amygdala connectivity in the default mode network, task positive network, and subcortical structures showed interacting influences of TBI and PTS, only between right amygdala and right putamen. These results suggest that mTBI and PTS are associated with hypo-frontal and hyper-posterior amygdala connectivity. Additionally, comorbidity of these conditions appears to compound these neural activity patterns. PTS in mTBI may change neural resource recruitment for information processing between the amygdala and other brain regions and networks, not only during emotional processing, but also at rest.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article