Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?
Int J Mol Sci
; 24(15)2023 Jul 26.
Article
em En
| MEDLINE
| ID: mdl-37569352
ABSTRACT
A great deal of evidence has revealed an important link between gut microbiota and the heart. In particular, the gut microbiota plays a key role in the onset of cardiovascular (CV) disease, including heart failure (HF). In HF, splanchnic hypoperfusion causes intestinal ischemia resulting in the translocation of bacteria and their metabolites into the blood circulation. Among these metabolites, the most important is Trimethylamine N-Oxide (TMAO), which is responsible, through various mechanisms, for pathological processes in different organs and tissues. In this review, we summarise the complex interaction between gut microbiota and CV disease, particularly with respect to HF, and the possible strategies for influencing its composition and function. Finally, we highlight the potential role of TMAO as a novel prognostic marker and a new therapeutic target for HF.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Microbioma Gastrointestinal
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Insuficiência Cardíaca
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article