Stimuli-responsive assembly and disassembly of anionic suprasomes with tunable antibacterial activity.

Prusty, Biswa Mohan; Karn, Rama; Patel, Anjali; Mazumder, Priyanka; Kumar, Sachin; Manna, Debasis

Prusty, Biswa Mohan; Karn, Rama; Patel, Anjali; Mazumder, Priyanka; Kumar, Sachin; Manna, Debasis.

Afiliação

Prusty BM; Department of Chemistry, Indian Institute of Technology Guwahati, Assam-781039, India. dmanna@iitg.ac.in.
Karn R; Centre for the Environment, Indian Institute of Technology Guwahati, Assam-781039, India.
Patel A; Centre for the Environment, Indian Institute of Technology Guwahati, Assam-781039, India.
Mazumder P; Centre for the Environment, Indian Institute of Technology Guwahati, Assam-781039, India.
Kumar S; Department of Bioscience and Bioengineering, Indian Institute of Technology Guwahati, Assam-781039, India.
Manna D; Department of Chemistry, Indian Institute of Technology Guwahati, Assam-781039, India. dmanna@iitg.ac.in.

Chem Commun (Camb) ; 59(71): 10624-10627, 2023 Aug 31.

Article em En | MEDLINE | ID: mdl-37578258

ABSTRACT

ABSTRACT

Host-guest complexation-based suprasomes successfully deliver benzimidazolium amphiphiles. ß-CD and Zn2+ or an acidic environment act as the stimuli for the assembly and disassembly of suprasomes. The supramolecular nanomedicine developed by encapsulating tetracycline showed strong and tunable antibacterial activity and holds potential for the next-generation vesicle-based drug delivery system.

Assuntos

Antibacterianos; Sistemas de Liberação de Medicamentos; Antibacterianos/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas de Liberação de Medicamentos / Antibacterianos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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