Silencing of Perilipin 3 Inhibits Lung Adenocarcinoma Cell Immune Resistance by Regulating the Transcription of PD-L1 Through c-Myc.

Men, Xuelin; Zhu, Wei

Men, Xuelin; Zhu, Wei.

Afiliação

Men X; Department of Respiratory and Critical Care II, The Fourth People's Hospital of Jinan, Jinan, Shandong, P.R. China.
Zhu W; Department of Respiratory and Critical Care II, The Fourth People's Hospital of Jinan, Jinan, Shandong, P.R. China.

Immunol Invest ; 52(7): 815-831, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37578465

1. Silencing of PLIN3 inhibited tumour growth in vivo and in vitro.2. Silencing of PLIN3 inhibited PD-L1 expression and Myc pathway in LUAD cells.3. c-Myc acted as a transcription factor of PD-L1.4. Silencing of PLIN3 exerted anti-tumour effects by regulating c-Myc/PD-L1.

Assuntos

Adenocarcinoma de Pulmão; Adenocarcinoma; Neoplasias Pulmonares; Humanos; Adenocarcinoma de Pulmão/genética; Antígeno B7-H1/genética; Antígeno B7-H1/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/genética; Neoplasias Pulmonares/metabolismo; Perilipina-3

Palavras-chave

Lung adenocarcinoma; Myc pathway; PD-L1; PLIN3; tumour growth

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Adenocarcinoma de Pulmão / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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