Balancing lysosome abundance in health and disease.

Mutvei, Anders P; Nagiec, Michal J; Blenis, John

Mutvei, Anders P; Nagiec, Michal J; Blenis, John.

Afiliação

Mutvei AP; Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Huddinge, Sweden. anders.mutvei@ki.se.
Nagiec MJ; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. anders.mutvei@ki.se.
Blenis J; Meyer Cancer Center and Department of Pharmacology, Weill Cornell Medical College, New York, NY, USA.

Nat Cell Biol ; 25(9): 1254-1264, 2023 09.

Article em En | MEDLINE | ID: mdl-37580388

ABSTRACT

ABSTRACT

Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes.

Assuntos

Lisossomos; Organelas; Humanos; Lisossomos/metabolismo; Homeostase; Transdução de Sinais; Autofagia/fisiologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Organelas / Lisossomos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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