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Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities.
Li, Xuemei; Wang, Peipei; Wang, Chang; Jin, Tingting; Xu, Ran; Tong, Lexian; Hu, Xiaobei; Shen, Liteng; Li, Jia; Zhou, Yubo; Liu, Tao.
Afiliação
  • Li X; ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.R. China.
  • Wang P; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China.
  • Wang C; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China.
  • Jin T; Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou310006, P.R. China.
  • Xu R; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China.
  • Tong L; ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.R. China.
  • Hu X; Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou 310018, P. R. China.
  • Shen L; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, P.R. China.
  • Li J; Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan Tsuihang New District,Guangdong 528400, P. R. China.
  • Zhou Y; Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou310058, P.R. China.
  • Liu T; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China.
J Med Chem ; 66(17): 11792-11814, 2023 09 14.
Article em En | MEDLINE | ID: mdl-37584545
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article