The impact of sarcopenia on esophagectomy for cancer: a systematic review and meta-analysis.
BMC Surg
; 23(1): 240, 2023 Aug 17.
Article
em En
| MEDLINE
| ID: mdl-37592262
ABSTRACT
BACKGROUND:
Esophagectomy is the gold-standard treatment for locally advanced esophageal cancer but has high morbimortality rates. Sarcopenia is a common comorbidity in cancer patients. The exact burden of sarcopenia in esophagectomy outcomes remains unclear. Therefore, this systematic review and meta-analysis were performed to establish the impact of sarcopenia on postoperative outcomes of esophagectomy for cancer.METHODS:
We performed a systematic review and meta-analysis comparing sarcopenic with non-sarcopenic patients before esophagectomy for cancer (Registration number CRD42021270332). An electronic search was conducted on Embase, PubMed, Cochrane, and LILACS, alongside a manual search of the references. The inclusion criteria were cohorts, case series, and clinical trials; adult patients; studies evaluating patients with sarcopenia undergoing esophagectomy or gastroesophagectomy for cancer; and studies that analyze relevant outcomes. The exclusion criteria were letters, editorials, congress abstracts, case reports, reviews, cross-sectional studies, patients undergoing surgery for benign conditions, and animal studies. The meta-analysis was synthesized with forest plots.RESULTS:
The meta-analysis included 40 studies. Sarcopenia was significantly associated with increased postoperative complications (RD 0.08; 95% CI 0.02 to 0.14), severe complications (RD 0.11; 95% CI 0.04 to 0.19), and pneumonia (RD 0.13; 95% CI 0.09 to 0.18). Patients with sarcopenia had a lower probability of survival at a 3-year follow-up (RD -0.16; 95% CI -0.23 to -0.10).CONCLUSION:
Preoperative sarcopenia imposes a higher risk for overall complications and severe complications. Besides, patients with sarcopenia had a lower chance of long-term survival.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcopenia
/
Neoplasias
Tipo de estudo:
Guideline
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article