Bioactive diterpenoids isolated from the twigs and leaves of Casearia velutina.
Fitoterapia
; 171: 105654, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37595644
ABSTRACT
Nine previously undescribed clerodane-type diterpenoids (1-9), named caseabalanspenes A-I, along with six know compounds (10-15), were isolated from the twigs and leaves of Casearia velutina. Spectroscopic data (1D and 2D NMR) analysis permitted the definition of their structures and then determination of the molecular formula of the compound by high resolution mass spectrometry (HR-ESI-MS). It is worth noting that compound 7 contains N- heterocycle. Compounds 1-8 were tested the anti-inflammasome activity, and compound 3 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC50 values of 2.90 µM.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Casearia
/
Diterpenos Clerodânicos
/
Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article